Monitor diuretic effect and blood pressure when used in combination with CYP2C9 inhibitor or inducer. The recommended initial dose is 5 mg once daily. [see Warnings and Precautions ( No overall increase in tumor incidence was found when torsemide was given to rats and mice throughout their lives at doses up to 9 mg/kg/day (rats) and 32 mg/kg/day (mice). The tests included the Ames test in bacteria (with and without metabolic activation), tests for chromosome aberrations and sister-chromatid exchanges in human lymphocytes, tests for various nuclear anomalies in cells found in hamster and murine bone marrow, tests for unscheduled DNA synthesis in mice and rats, and others. 03/17 (P) Get contact details and address | ID: 21762875733 Of the total number of patients who received torsemide in United States clinical studies, 24% were 65 or older while about 4% were 75 or older. In these patients, diuresis with torsemide is best initiated in the hospital. Do not take two doses at one time. Torsimide (Demadex) comes in tablets of 5, 10, 20, and 100 mg. (, Non-steroidal anti-inflammatory drugs (NSAIDs): Reduced diuretic, natriuretic, and antihypertensive effects; risk of renal impairment. defined in the USP, with a child-resistant closure Doses higher than 40 mg have not been adequately studied in this population. NDC 42291-816-90 Your blood pressure will need to be checked often, and you may need other medical tests. Titrate by factors of two; doses above 40 mg have not been studied. There are no data regarding the presence of torsemide in human milk or the effects of torsemide on the breastfed child. It helps you make more urine and lose salt and water from your body. Rev. Torsemide injection is given either as a slow infusion over 2 minutes, or as a continuous (around the clock) infusion. Excessive diuresis may cause potentially symptomatic dehydration, blood volume reduction and hypotension and worsening renal function, including acute renal failure particularly in salt-depleted patients or those taking renin-angiotensin aldosterone inhibitors. If the administration of torsemide is suddenly stopped, blood pressure returns to pretreatment levels over several days, without overshoot. If you have cirrhosis or other liver problems, you may receive your first injection in a hospital or clinic setting to quickly treat any serious side effects. Torsemide 10 Tablet. [see Drug Interactions ( & Articles, All Torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates or of substrates with a narrow therapeutic range, such as warfarin or phenytoin. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Rev. AvKARE various other heart or blood tension drugs such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), as well as others; or. Manufactured for: Pulaski, TN 38478 If you are a consumer or patient please visit C Skin/hypersensitivity: Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity reaction, pruritus Urogenital: Acute urinary retention The drug is absorbed with little first-pass metabolism, and the serum concentration reaches its peak (C However, in pregnant rats and rabbits administered 50 and 6.8 times the human dose, respectively, decreases in body weight, decreased fetal resorption and delayed fetal ossification was observed. In healthy subjects given single doses, the dose-response relationship for sodium excretion is linear over the dose range of 2.5 mg to 20 mg. This effect has been reported with concomitant use of torsemide and gentamycin. Available for Android and iOS devices. max and area under the serum concentration-time curve (AUC) after oral administration are proportional to dose over the range of 2.5 mg to 200 mg. To report SUSPECTED ADVERSE REACTIONS, contact AvKARE, Inc. at 1-855-361-3993 or FDA at 1-800-FDA-1088 or Select Quantity. If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. Because torsemide and salicylates compete for secretion by renal tubules, patients receiving high doses of salicylates may experience salicylate toxicity when torsemide is concomitantly administered. A healthcare provider may teach you how to properly use the medication by yourself. Rx only Torsemide tablets are indicated for the treatment of hypertension, to lower blood pressure. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. In stock Manufacturer RISING PHARM 57237014101. In the U.S. general population, the estimated background risk of major malformations and miscarriage in clinically recognized pregnancies is 2 to 4%, and 15 to 20%, respectively. The recommended initial dose is 5 mg or 10 mg oral torsemide tablets once daily, administered together with an aldosterone antagonist or a potassium-sparing diuretic. Usual dosage: See package insert for full prescribing information. Dispense in a tight, light-resistant container as If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained. $0.43 / Tablet. RxNorm, Sign-In Client ID: Password: Forgot your password? Torsemide is a substrate of CYP2C9. Torsemide is indicated for the treatment of edema associated with heart failure, renal disease, or hepatic disease. If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, tell your caregivers that you currently take torsemide. NDC 42291-818-90 Patients can take the tablets at any time without regard to meals. The total clearance of torsemide is approximately 50% of that seen in healthy volunteers, and the plasma half-life and AUC are correspondingly increased. KEEP THIS AND ALL MEDICATION OUT OF THE Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This medicine is used to treat high blood pressure, and edema or swelling from heart, kidney, or liver disease. Tablet. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. In doses up to 25 mg/kg/day (75 times a human dose of 20 mg on a body-weight basis; 13 times this dose on a body-surface-area basis), torsemide had no adverse effect on the reproductive performance of male or female rats. Dosages of Torsemide: Dosage Forms and Strengths. Monitor volume status and renal function periodically. 42291-817-90, Dispense in a tight, light-resistant container as Concomitant use with torsemide may increase risk of hypokalemia. 7.1)] It also treats high blood pressure. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Rev. Simultaneous food intake delays the time to C Higher than recommended doses, severe renal impairment, and hypoproteinemia, appear to increase the risk of ototoxicity. Discontinuation of therapy due to adverse reactions occurred in 3.5% of United States patients treated with torsemide and in 4.4% of patients treated with placebo. See 17 for PATIENT COUNSELING INFORMATION. is this? What is torsemide? prescribing information. REACH OF CHILDREN. Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and torsemide has been associated with the development of acute renal failure. TORSEMIDE (TORE se mide) is a diuretic. Torsemide can increase the risk of renal toxicity related to administration of radiocontrast agents. Torsemide is contraindicated in patients with hepatic coma. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, increase to 10 mg once daily. When given with aldosterone antagonists, torsemide also caused increases in sodium and fluid excretion in patients with edema or ascites due to hepatic cirrhosis. Torsemide is the only diuretic, the effectiveness of which is confirmed in large multicenter studies. Store in a dry place. No mutagenic activity was detected in any of a variety of However, because of the increased renal clearance of torsemide in patients with hepatic cirrhosis, these factors tend to balance each other, and the result is an overall natriuretic response that is similar to that seen in healthy subjects. Follow your doctor's orders or the directions on the label. We comply with the HONcode standard for trustworthy health information -. Torsemide Tablets are available as white to off white scored tablets in 5-, 10-, 20-, and 100-mg strengths. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Torsemide oral is taken by mouth. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=7fc14338-92e4-cf57-a3e8-ef64d8d1026c, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. It’s also used to treat edema (fluid retention) due to conditions such as heart, liver, or kidney disease. Torsemide 100 Mg - A month's worth of pills is available from wholesalers for less than $20. Mfg. mg torsemide, USP. In normal subjects the elimination half-life of torsemide is approximately 3.5 hours. The changes subsided with chronic therapy. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you are sick with vomiting or diarrhea. prescribing information. Torsemide is provided to help in reducing the quantity of water in the body in specific disorders, such as coronary infarction, extreme liver condition (cirrhosis), or kidney disease. Torsemide is a loop diuretic (water pill) that is used to treat fluid retention (edema) in people with heart failure, liver disease, or kidney disease. Pulaski, TN 38478 16H Torsemide is contraindicated in patients with known hypersensitivity to torsemide. max by about 30 minutes, but overall bioavailability (AUC) and diuretic activity are unchanged. (, Hepatic Cirrhosis: Initial dose is 5 or 10 mg once daily. A dose of 20 milligrams daily has been examined in some medical researches. Dispense in a tight, light-resistant container as Each tablet contains 10 mg torsemide, USP. After 4 to 6 weeks, increase to 10 mg once daily, if needed. Torsemide does not affect the protein binding of glyburide or warfarin. This drug is also used to treat high blood pressure. In long-term studies in diabetics, mean fasting glucose values were not significantly changed from baseline. Some things can cause your blood pressure to get too low. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Torasemide HEXAL 100 mg kasutamine võib anda positiivse tulemuse dopingukontrollis. Events, (What (, Hypotension and worsening renal function: monitor volume status and renal function periodically (, Electrolyte and metabolic abnormalities: monitor serum electrolytes and blood glucose periodically. Updated This includes vomiting, diarrhea, or heavy sweating. Monitor diuretic effect and blood pressure during coadministration. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Like other diuretics, torsemide reduces the renal clearance of lithium, inducing a high risk of lithium toxicity. AvKARE defined in the USP, with a child-resistant closure Available in bottles of 90 (NDC 42291-818-90). Torsemide is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. An increase in diuresis may also take place if other diuretics are no longer active, eg in the presence of impaired renal function. In patients followed for 1 year, there was no progressive change in mean serum potassium levels. Torsemide could enhance the amount of pee or induce you to pee much more typically when you first begin taking it. Symptomatic Hypotension: Advise patients receiving torsemide that lightheadedness can occur, especially during the first days of therapy, and that it should be reported to the prescribing physician. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. in vitro tests of torsemide and its major human metabolite. Urinary sodium excretion rate relative to the urinary excretion rate of torsemide is less in cirrhotic patients than in healthy subjects (possibly because of the hyperaldosteronism and resultant sodium retention that are characteristic of portal hypertension and ascites). The lowest GoodRx price for the most common version of torsemide is around $9.00, 47% off the average retail price of $17.10. Files, All Mapping Usual dosage: See package insert for full Torsemide Tablets are available as follows: 5 mg - White to off white, round, biconvex tablets, debossed with “PA” and “915” on one side and scored on the other side. Partial inhibition of the natriuretic effect of torsemide by concomitant administration of indomethacin has been demonstrated for torsemide under conditions of dietary sodium restriction (50 mEq/day) but not in the presence of normal sodium intake (150 mEq/day). In patients with essential hypertension, torsemide has been shown in controlled studies to lower blood pressure when administered once a day at doses of 5 mg to 10 mg. N3 4229181690 9, Torsemide Tablets 10 mg, 90s Label Text It is not known whether torsemide will harm an unborn baby. The recommended initial dose is 20 mg oral torsemide tablets once daily. Controlled Room Temperature]. Weekly. 20N Torsemide Available in bottles of 90 (NDC 42291-816-90). 90 Tablets In some cases, drinking too much liquid can be as unsafe as not drinking enough. 12.2)] Copyright 1996-2021 Cerner Multum, Inc. Administration of another loop diuretic to premature infants has been associated with the precipitation of nephrocalcinosis/nephrolithiasis. Digoxin: Coadministration of digoxin is reported to increase the AUC for torsemide by 50%, but dose adjustment of torsemide is not necessary. Loop diuretics increase the ototoxic potential of other ototoxic drugs, including aminoglycoside antibiotics and ethacrynic acid. 4), The most common adverse reaction is excessive urination (6.7%). The antihypertensive and diuretic effects of torsemide can be reduced by NSAIDs. Tablets Gastrointestinal system: Pancreatitis, abdominal pain, Nervous System: Paresthesia, confusion, visual impairment, loss of appetite, Hematologic: Leucopenia, thrombocytopenia, anemia, Hepatobiliary: Increase in liver transaminases, gamma-glutamyltransferase, Metabolism: Thiamine (vitamin B1) deficiency. Its chemical name is 1-isopropyl-3-[(4- Store at 20° to 25°C (68° to 77°F) [See USP prescribing information. With oral dosing, the onset of diuresis occurs within 1 hour and the peak effect occurs during the first or second hour and diuresis lasts about 6 to 8 hours.